Driven by the need to discover new drug leads for the treatment of Alzheimer’s disease, Dos Santos et al. [65] screened the acetylcholinesterase (AChE) inhibitory activity of derivatives of trachyloban-19-oic acid obtained by biotransformation with Syncephalastrum racemosum. The enzymatic oxidation and rearrangement of the parent compound afforded three metabolites with improved biological activity. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.