In regards to PDE4D/rs295978 polymorphism, the mutated genotypes (GG and CG) were associated with reduced ODD of obesity but was statistically insignificant (OR = 0.5, 95% CI = 0.1969 to 1.5767, p = 0.2 and OR = 0.7, 95% CI = 0.3520 to 1.7490, p = 0.5, respectively). This evidence concerns the gene PDE4D and obesity due to melanocortin 4 receptor deficiency.