However, the cytotoxic activities of 1 are associated with the generation of ROS, and previous studies have demonstrated that 1 exhibited antiproliferative action via leading decreases of the expression of some key proteins (HER, JAK 1 and 2, STAT3, c-MET, GSTP1, JNK) that are responsible for the development of various cancer types [24,25,26]. This evidence concerns the gene MAPK8 and cancer.