LEP and obesity due to melanocortin 4 receptor deficiency: In men leptin was 1.88 ± 0.76 ng/mL in those with low BMI, 5.09 ± 4.57 ng/mL in those with normal BMI, 9.70 ± 4.14 ng/mL in those where the BMI indicated being overweight, and 20.41 ± 14.99 ng/mL in those where the BMI indicated obesity.