CCN4 and hepatocellular carcinoma: As shown in Fig 1 and Table 6, compared with the A-C reference group (WISP1 rs62514004/rs16893344), carriers with A-T or G-C had significant 0.339-fold (95% CI 0.219–0.524) and 0.190-fold (95% CI 0.100–0.363) lower risks of HCC.