Compared with the WISP1 SNP rs62514004 and rs16893344 WT A-C haplotype control group, we found that the WISP1 SNP rs62514004 and rs16893344 G-T haplotype carried a greater risk for HCC, whereas the A-T and G-C haplotypes represented lower risk of HCC (Table 6). Here, CCN4 is linked to hepatocellular carcinoma.