Distribution frequencies of clinical statuses and WISP1 genotypes in patients with HCC were estimated to understand the effect of the WISP1 SNPs on clinical stage, tumor size, vascular invasion, lymph node metastasis, distant metastasis, Child—Pugh grade, HBsAg and liver cirrhosis. This evidence concerns the gene CCN4 and metastatic malignant neoplasm in the lymph nodes.