CCN4 and hepatocellular carcinoma: Furthermore, we identified a combined effect of alcohol drinking with the WISP1 rs62514004 and rs16893344 G-T haplotype; a synergistic effect with alcohol drinking not only negated the tumor-suppressing activity of WISP1 rs62514004 and rs16893344 polymorphisms but also resulted in a poorer prognosis for HCC development.