CCN4 and hepatocellular carcinoma: Connections between retinoid depletion, upregulation of Wnt signaling, HCC tumor promotion, and increased hepatocyte proliferation were suggested by Mercer et al., and the WISP1 gene exhibited the highest relative expression among Wnt signaling components and β-catenin targets, with a 3.3-fold change following EtOH consumption in rats [36].