This hypothesis of differential network involvement and our results are in line with pathological studies: tau deposition is extensively found in the hippocampus and other limbic structures in the early phases of FTD due to MAPT mutations [21]; dipeptide repeat proteins (DPRs), together or without TDP-43 deposition, are found in the CA subregions in C9orf72, and DPRs are also found in the cerebellum and the thalamus; while TDP-43 accumulates in the hippocampus and the cortex in GRN. Here, TARDBP is linked to frontotemporal dementia.