Several recent reports indicate that TβRII expression is largely regulated by microRNA 21 (miR‐21) in both stromal (adipose tissue‐derived mesenchymal stem cells) and epithelial cells (colon cancer cell lines, HCT‐116 and HT‐29).42, 43 miR‐21 regulates TβRII expression through direct interaction with the 3′ non‐translated region in the TβRII transcript. The gene discussed is TGFBR2; the disease is malignant colon neoplasm.