Several recent reports indicate that TβRII expression is largely regulated by microRNA 21 (miR‐21) in both stromal (adipose tissue‐derived mesenchymal stem cells) and epithelial cells (colon cancer cell lines, HCT‐116 and HT‐29).42, 43 miR‐21 regulates TβRII expression through direct interaction with the 3′ non‐translated region in the TβRII transcript. This evidence concerns the gene TGFBR2 and colonic neoplasm.