NFKB1 and neoplasm: The Δ133p53 isoforms and the animal model ‘mimics’ are associated with increased NFκβ signalling followed by increased cytokine production; so it is likely that Δ133p53β contributes directly to the immunosuppression in glioblastoma by influencing the cytokines produced in the tumor environment 9, 13, 18, 47, 48.