Figure 3C). These findings indicate that amylase increases rapamycin-induced autophagy. Next, we investigated the effect of cerulein, a pancreatitis-inducing agent. We observed less LC3-II in Amy2-deficient clones than in wild-type clones (Figure 4(c)). Moreover, in Amy2-deficient clones, we did not detect an increase in LC3 puncta (Figure 4(b), Supp.  Figure 3C). The gene discussed is MAP1LC3A; the disease is pancreatitis.