Although Krasteva and colleagues reported no statistically significant difference in the salivary level of IgA, assessed by radial immunodiffusion, between psoriasis patients and healthy controls, they observed that patients with a PASI > 10 had a tendency to show lower levels of IgA, compared to patients with a PASI < 10, suggesting that patients with a PASI > 10 might be at high risk of developing microbial infections that could trigger psoriasis [25]. The gene discussed is CD79A; the disease is psoriasis.