CD97 cytoplasmic location correlated with tumor budding (p = 0.041) as seen in Figure 4E. As for CD97, in most specimens (102/111), the staining score for β-catenin at the membrane was lower in malignant compared to normal enterocytes, whereas in 87/111 specimens, cytoplasmic β-catenin was higher in the tumor. Here, ADGRE5 is linked to neoplasm.