Though the authors linked SLC25A1 expression to anchorage-independent growth of NCI-H460 cancer cells (36), it was tempting to speculate that the function of SLC25A1 regarding maintenance of redox homeostasis and mitochondrial function might contribute to the increased radioresistance of lung cancer cells with tolerance to chronic hypoxia/reoxygenation stress. The gene discussed is SLC25A1; the disease is lung cancer.