IDH2 and lung carcinoma: Interestingly, exposure to acute severe hypoxia (0.2% O2) was also able to trigger increased expression of SLC25A1 and IDH2 in the lung cancer cells and this effect was observed in both, oxic and anoxia-tolerant NCI-H460 cancer cells, compared to the oxic NCI-H460 control cells under normoxic (Nx) conditions (Figures 1D,E).