PML NBs have been functionally linked to apoptosis (49), nuclear proteolysis (50), senescence (51), stem cell renewal (52, 53), regulation of gene expression (54), tumor suppression (55), the DNA damage response (40, 41, 56), telomere elongation and stability (47, 57), epigenetic regulation (37, 58), and antiviral responses (59) (Figure 2C). Here, PML is linked to neoplasm.