VEGFA and hepatocellular carcinoma: The importance of VEGFA isoforms fractions evaluation is clearly illustrated by the fact that changes in VEGFA isoform fractions, but not in their expression levels, are associated with such essential HCC clinicopathological features as TNM and BCLC stages, the latter currently being considered the most effective system for HCC prognosis and treatment optimization (Edge et al., 2010; Bruix, Reig & Sherman, 2016).