VEGFA and hepatocellular carcinoma: A number of VEGFA pathway inhibitors are currently under investigation or already approved for clinical use like bevacizumab, sunitinib, sorafenib, and regorafenib, the last two being the most efficient drugs for therapy of advanced HCC (Shen, Hsu & Cheng, 2010; Rapisarda & Melillo, 2012; Bruix et al., 2017).