KEAP1 and obesity due to melanocortin 4 receptor deficiency: Obesity and DEHP significantly increased the levels of Keap1 protein by 130%, 117%, 135%, 129%, and 167% in the DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high groups, respectively, compared to the controls (P < 0.05).