At 12 weeks, the obesity and DEHP had reduced SOD levels to 46%, 68.9%, 54%, 45.6%, and 34.7% of the control in the DEHP, DIO, DIO + DEHP low, DIO + DEHP middle, and DIO + DEHP high mice, respectively (P < 0.01). Here, SOD1 is linked to obesity due to melanocortin 4 receptor deficiency.