Currently, the most widespread used biomarkers in PaC are CA19-9, CA-125, carcinoembryonic antigen (CEA), MMP-9, K-ras, and p53, but these biomarkers often lead to inadequate specificity (SPE) and unreliable sensitivity (SEN) of PaC and are not recommended for primary screening tools and early disease diagnosis [4]. This evidence concerns the gene MMP9 and gonorrhea.