Likewise, IL-6−/− (8), IL-6 signaling-deficient (10), STAT3−/− (86), glucocorticoid-induced tumor necrosis factor receptor related protein (GITR)-deficient mice (87), and mice with a T cell-specific deletion of the miR17–92 family of microRNAs (88) fail to elicit or maintain a TFH cell response upon (persistent) LCMV infection and are unable to eventually control the infection. This evidence concerns the gene IL6 and infection.