Since we previously reported that after HCMV infection M1- and M2-Mφ exhibit features of classical activation, expressing high levels of co-stimulatory and MHC class I molecules and secreting high amounts of inflammatory cytokines and chemokines (25), we decided to investigate (i) whether the immune evasive genes US2, US3, US6, and US11 were expressed during HCMV infection in Mφ; (ii) which impact these genes exerted on the expression and function of MHC class I and class II molecules, and (iii) whether IE+ infected Mφ could directly present antigens to T cells. The gene discussed is RPS14; the disease is cytomegalovirus infection.