To further determine whether TREM2 modulated host defense against P. aeruginosa through regulating caspase-1 activation and pyroptosis, C57BL/6 mice were subconjunctivally injected with caspase-1 siRNA or caspase-1-specific inhibitor YVAD, followed by routine P. aeruginosa corneal infection. Here, CASP1 is linked to corneal infection.