The authors identified that CRC, where higher expression of FOXP3 was associated with favorable outcomes, were actually infiltrated more with FOXP3loCD45RA+ effector T-cells and upregulated inflammatory genes like Il12a, Il12b, Tgfb1, and Tnf. Higher infiltration of FOXP3hiCD45RA− cells resulted in poor prognosis and lower disease-free survival (205) as reported for other tumors. This evidence concerns the gene FOXP3 and colorectal carcinoma.