NGF and dementia: The Kuhn group clearly acknowledged the paucity of preclinical evidence when concluding that preclinical studies so far “almost exclusively were observed in naïve animals not actually suffering from dementia, therefore lacking the structural damages as well as the pathophysiology typically underlying dementia.” [68] However, such studies would seem to be necessary to find out whether the preliminary effects found in healthy animals, e.g. NGF release or enhanced neuronal activity, can also be expected in animal models of dementia.