SH3BP2 and mastocytosis: Moreover, SH3BP2 regulates wild‐type KIT and mutated D816V KIT expression (Ainsua‐Enrich et al., 2015), a hallmark mutation in mastocytosis, which is a rare disease comprising MC leukemia characterized by aberrant growth and accumulation of clonal MCs in different organs (Metcalfe and Mekori, 2017).