TAT and Opportunistic infection: This PI(4,5)P2-targeting toxin is likely involved in the development of (i) opportunistic infections, due to its capacity to inhibit phagocytosis20, (ii) HIV-1 associated neurological disorders due to Tat ability to impair neurotransmitter secretion21 and (iii) cardiac disorders linked to Tat inhibition of key cardiac ion channels22.