HMGB1P46 and diabetes mellitus: Other GWA studies of neuropathic pain in patients with diabetes have shown the significance of Chr8p21.3 (GFRA2)30 and sex-specific involvement of Chr1p35.1 (ZSCAN20-TLR12P) for females and Chr8p23.1 (HMGB1P46) for males for diabetic neuropathic pain31.