Interestingly, we observed higher early and late HIV-1 RT products upon HIV-1 infection in absence of Vpx (-Vpx) in mitotic cells, which displayed high SAMHD1 pT592-levels (“inf + N”), than compared to CD4+ T cells that entered G1 phase characterized by a reduced pT592 signal (“inf”) (Fig. 7b, d, “-Vpx”). The gene discussed is SAMHD1; the disease is HIV-1 infection.