Strikingly, infection with HIV-1 in the presence of Vpx (Supplementary Fig. 6g), which leads to degradation of SAMHD1 (Supplementary Fig. 6h), does not change the levels of RT products; the infection rates are comparable between G2/M and G1 phase (Supplementary Fig. 6g). The gene discussed is SAMHD1; the disease is infection.