The constructed gene networks revealed among the exome genes, partners previously implicated in autoimmune diseases, including the SLE-associated genes IKZF1, IKZF3, and ITGAX25,50,51 (Tables 3 and S6), further supporting a role for the genes identified in the disease pathogenic pathways. The gene discussed is IKZF3; the disease is systemic lupus erythematosus.