The resulting network included twelve genes, of which the SLE associated genes EMC10 and DCLRE1C, together with NUP214, CHD3, NOTCH1, FAM8A1, MPHOSPH8, TPRA1 and CLC showed high connectivity to each other and to other genes in the network via several partners. This evidence concerns the gene NOTCH1 and systemic lupus erythematosus.