In family 8, five out of seven SLE relatives carried the variants in DCLRE1C (MIM 605988) (p.H283N), NOTCH1 (MIM 190198) (p.D932N), FBXL14 (MIM 609081) (p.N102H) and CLC (MIM 153310) (p.N65K) (Table 1). The gene discussed is NOTCH1; the disease is systemic lupus erythematosus.