For example, several other genes involved in DNA repair pathways have been previously found associated with SLE: TREX1 (3′ repair exonuclease 1)65,66 and X-Ray Repair Complementing Defective Repair genes including XRCC1, XRCC3, and XRCC467,68. This evidence concerns the gene TREX1 and systemic lupus erythematosus.