Subject motion did not change over time (Supplementary Fig. 3) and including subject motion as a covariate in the model did not change the results: MD decreased as a function of intervention hours within the left AF (F(1,76) = 10.48, p = 0.0018) and the left ILF (F(1,76) = 9.53, p = 0.0028), but not within the CC (F(1,76) = 2.11, p = 0.15). The gene discussed is FOXK2; the disease is atrial fibrillation.