Accordingly, inactivation of CREB-expressing neurons in the non-stroke groups caused a significant deficit in motor control in pasta handling and grid-walking (Fig. 2b) compared with mice transfected with viral vectors with hM4Di but without CREB (****P < 0.0001, F (5, 372) = 63.86; ****P < 0.0001, F (5, 372) = 63.86; Fig. 3f, g, Supplementary Fig. 10). This evidence concerns the gene CREB1 and stroke disorder.