CREB1 and Stroke: In stroke control virus, recovery was observed only by 12 weeks in grid walking (Stroke control virus vs Stroke CREB; 4 weeks: ***P < 0.001; 8 weeks: **P < 0.005; F (3, 160) = 19.90), while there was still a persistent deficit in the pasta-handling task (Stroke control virus vs Stroke CREB; 3 weeks: ****P < 0.0001, 5 weeks: ****P < 0.0001, F (3, 160) = 36.26; Fig. 2b, c).