Beginning at 7 weeks in pasta handling (F (2, 111) = 22.44; P < 0.0012) and at 11 weeks in gridwalking (F (2, 124) = 41.63; P < 0.0093), there is a significant improvement in motor performance in lenti-CREB compared to stroke + control virus. The gene discussed is CREB1; the disease is Stroke.