CREB1 and Stroke: Remarkably, lenti-CREB delivery to a pool of motor cortical neurons anterior to the stroke site significantly improves functional recovery of motor control within 3–4 weeks in grid and pasta handling tasks (grid-walking: 4 weeks ***P < 0.001, F (3, 160) = 19.90; pasta handling: 3 weeks ****P < 0.0001, F (3, 160) = 36.26; Fig. 2b, c).