In the pasta handling task, both groups of mice in which CREB is induced (with stroke and in non-stroke) perform worse than stroke + hM4Di + CNO (****P < 0.0001, F (5, 372) = 63.86; Fig. 3g, Supplementary Fig. 10), indicating that inhibition of CREB transduced neurons causes a worse motor deficit than inhibition of a similar number of neurons without CREB induction. Here, CREB1 is linked to stroke disorder.