New connections in peri-infarct cortex in stroke can be detected in both genetic approaches in delivery of CREB; in particular we observed a significant increase in BDA-labeled projections after stroke in motor cortex in lenti-CREB (n = 4, Hotelling’s t2 test P < 0.021) mice with stroke when compared, respectively, with their controls (CREB virus alone, Fig. 6c, d) or with the control virus (control (non-CREB) virus plus stroke, P < 0.029) (Fig. 6e, f). Here, CREB1 is linked to stroke disorder.