Similar to observations in MPS I, IIIA, and IIIB mice (Wilkinson et al, 2012), we also identified significant increases in macrophage inflammatory protein (MIP‐1α/CCL3), interleukin‐1α (IL‐1α) protein, RANTES (CCL5), and monocyte chemoattractant protein (MCP‐1/CCL2) in the brains of untreated MPS II animals (Fig 6A–D). Here, IL1A is linked to mucopolysaccharidosis type 2.