We previously showed that lentiviral vectors under the myeloid‐specific CD11b promoter were able to mediate neurological correction in mouse models of MPS IIIA (Sergijenko et al, 2013) and MPS IIIB (Holley et al, 2017), following delivery of the missing enzyme via HSCGT. The gene discussed is ITGAM; the disease is mucopolysaccharidosis type 3A.