HK1 and leukemia: These results support the hypothesis that post-translational modification of the glycolytic enzyme PK M2 (e.g. by pharmacological modulation with P-M2tide or DASA), without any detectable change in mRNA levels of PK M2 and of any of the other glycolytic enzymes, may be sufficient to make leukemia cells resistant to chemotherapeutic agents such as fludarabine.