Cimpean et al. defined these different patterns of CK8/18 in breast cancer; diffuse cytoplasmic, membranous and combined cytoplasmic and membranous [19].Some researchers have proposed that loss of CK8/18 expression/low CK8/18 is associated with worse prognosis and high risk of metastasis [24, 25]. The gene discussed is KRT8; the disease is breast carcinoma.