Nivolumab, an anti-programmed cell death-1 (PD-1) antibody, has emerged as a breakthrough medication for several advanced malignancies [1, 2]; however, it frequently induces thyroid dysfunction [3, 4], possibly by evoked autoimmunity, similar to other immune-related adverse events (irAEs) [5–10]. The gene discussed is PDCD1; the disease is Autoimmunity.