The average GSTM1-null genotype distribution frequency in controls was 49.83%, and the average genotype distribution frequency of the GSTM1-null genotype in patients with RCC was 48.63%, indicating the average GSTM1-null genotype distribution frequency in RCC patients was similar to that in the control group (control/RCC = 1.02), suggesting that the GSTM1-null genotype was unrelated to RCC. The gene discussed is GSTM1; the disease is renal cell carcinoma.