IL1B and infection: In addition, The NLR family pyrin domain containing 3 (NLRP3) inflammasome is a multiprotein complex that orchestrates innate immune responses to infection and cell stress through activation of caspase-1 (CASP1) and maturation of the inflammatory cytokines pro-interleukin-1β (pro-IL-1β) and pro-IL-18 [13].