Although all 10 of these genes were related to both inflammation and infection in the literature, we also found that two of these genes IL8 and SERPINA1 were associated with tissue adhesion, whereas six genes IL8, CREB1, RGS4, PTGER3, OPRM1, and FGFR1 were associated with and receptor internalization (Fig. 4). The gene discussed is CREB1; the disease is infection.