One natural extension of this model, which would be consistent with the pleiotropy observed as well as the PHACTR1 eQTL we detected in hCA, is that the same SNP influences the expression of two genes – EDN1 and PHACTR1 – which are expressed in CAD-relevant cells and could act together to contribute to vascular disease risk. The gene discussed is PHACTR1; the disease is coronary artery disorder.