SIRT1 and neuroblastoma: With the aim of determining whether the oxysterols 24-OH and 7-K are able to modulate the SIRT1-dependent neuroprotective pathway, the expression and synthesis of SIRT1 were measured after treatment of neuroblastoma SK-N-BE cells either with 24-OH (Fig. 1) or with 7-K (Fig. 2), both at the physiopathological concentration of 1 μM.