TLR4 and colorectal carcinoma: In conclusion, our findings indicate a significant role of TLR2–196 to 174 del, TLR4 Asp299Gly, TLR4 Thr399Ile, TLR9 T1273C and TLR9 T1486C polymorphic variants with susceptibility to CRC development and disease progression, thus affecting patients’ survival.