STAT3 and colorectal carcinoma: Studies have shown no significant differences in CRC development between wild type and TLR2 deficient mice [8, 27]; whereas, others have shown an increase in tumor growth and of IL-6, IL-17A and STAT3 levels in TLR2-deficient CRC mice, and a protective role of TLR against colitis-associated CRC [8, 28].