Thus, we aimed to a) evaluate the expression of -196 to -174 del allele in the TLR2 gene, the Asp299Gly and Thr399Ile polymorphisms in the TLR4 gene and the T1237 and T1486C polymorphisms of the TLR9 gene in patients with early CRC; b) compare their expression in patients with metastatic disease; c) determine whether patients carrying TLR alleles have an increased risk of recurrence and decreased overall survival and d) associate TLR polymorphisms with patients’ molecular profiling. Here, TLR4 is linked to metastatic neoplasm.