In conclusion, our findings indicate a significant role of TLR2–196 to 174 del, TLR4 Asp299Gly, TLR4 Thr399Ile, TLR9 T1273C and TLR9 T1486C polymorphic variants with susceptibility to CRC development and disease progression, thus affecting patients’ survival. The gene discussed is TLR9; the disease is colorectal carcinoma.