Examples of such tumor-promoting proteolytic mechanisms include CAF-mediated expression and activation of e.g., MMP1, MMP2, MMP3, and MMP9, which can disrupt tissue polarity and architecture, as well as enhance the abilities of cancer cells to suppress E-cadherin-mediated adhesion and navigate the stromal ECM constrains [102,103,104,105,106,107]. The gene discussed is CDH1; the disease is cancer.