SPNS2 and allergic asthma: In ovalbumin (OVA)-induced allergic asthma model, Spns2-knockout mice exhibited decreased count of eosinophils and lymphocytes as well as increased macrophage numbers in BAL fluid, elaborated blunted Th2-type response with significantly decreased levels of IL-4, IL-13 and IL-5, and diminished antigen-specific antibody production when compared with wild type littermates.