Early IFALD has been defined in some studies in the presence of transaminases and/or gamma-glutamyltransferase (GGT) (>1.5 upper limit of normal) and hyperbilirubinemia below 3 mg/dL, while the combination of persistent hyperbilirubinemia >6 mg/dL and the prolongation of prothrombin time mark the highest risk for severe IFALD and progression to end-stage liver disease [9,13]. The gene discussed is F2; the disease is Hyperbilirubinemia.