Recently, Molica et al. showed, using double knock-out mice for Panx1 and Apoliprotein E (Apoe) to evaluate Panx1 role in atherosclerosis, that Panx1 in this context is necessary for lymphatic function by contributing to the drainage of interstitial fluid and to the uptake of dietary fat from the gut [47]. Here, APOE is linked to atherosclerosis.