Accumulating evidence suggests that epithelial–mesenchymal transition (EMT) is an important step during the progression and metastasis of HCC, and many studies have proven that 10 ng/mL TGF-β1 successfully promotes EMT via the induction of Snail, ZEB1, and other transcription factors in HCC cells [27,34,35,36]. This evidence concerns the gene ZEB1 and hepatocellular carcinoma.