It is worth noting that Shin et al. discovered that (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one (BCI, an inhibitor of dual specific phosphatase 1/6 and mitogen-activated protein kinase) significantly inhibits the viability of H1299 cells as compared to H460 cells [45], suggesting that different mechanisms might exist in lung adenocarcinoma (H1299 and LTEP-A2 cells) and undifferentiated large cell lung carcinoma (H460 cells) cell lines. The gene discussed is DUSP1; the disease is lung adenocarcinoma.