Our current and future work aims to identify and elucidate the cardioprotective structures and mechanisms of fish PL that inhibit atherosclerosis, by applying a novel pro-drug/precursor approach [55] and by exploiting phospholipids containing ω3 PUFA within their structure, in order to reduce and inhibit the inflammatory and thrombotic PAF activity. The gene discussed is PCLAF; the disease is atherosclerosis.