GSK3B and melanoma: In a previous study, Lou et al. reported that 10 μmol/L BBR increased the phosphorylation of Akt in HepG2 cells [33], Song et al. reported that 10 μg/mL (>40 μmol/L) BBR increased the phosphorylation of AKT and GSK3β in B16F10 melanoma cells [35], and Gomes et al. reported that 5 μmol/L BBR increased mitochondrial membrane potential in C2C12 cells [21].