TGF-β downregulation has been linked to overcoming doxorubicin resistance in HCT116 colon cancer cells [178] and is shown to exert oxaliplatin resistance in colorectal cancer [177], high resistance of breast cancer cells to doxorubicin through EMT overexpression [179] as well as resistance of triple negative breast cancer cells to paclitaxel [180]. This evidence concerns the gene TGFB1 and breast cancer.