Thus, recent data showed that down-regulation of endothelial adhesion receptor CD31/PECAM-1 (platelet endothelial cell adhesion molecule-1) was associated with resistance against oxidative stress and DNA damage in angiosarcoma cells due to YAP (yes-associated protein) signaling, and inhibition of YAP by pazopanib re-sensitized cancer cells to doxorubicin [242]. The gene discussed is PECAM1; the disease is cancer.