Gyuraszova et al. have demonstrated that the small-molecule YM155, which is an inhibitor of BIRC5 (survivin), was capable of potentiating the cytotoxic effect of hypericin-mediated photodynamic therapy (HY-PDT) in two cell lines resistant to HY-PDT, HT-29 (colorectal adenocarcinoma) and A549 (lung adenocarcinoma) [159]. The gene discussed is BIRC5; the disease is colorectal adenocarcinoma.