For example, monesin, medicarpin, diallyl trisulfide, tunicamycin, and 5,7-dimethoxyflavone initiated up-regulation of death receptor 5 (DR5) in glioma, myeloid leukemia, human melanoma and hepatocellular carcinoma cells via the unfolded protein response [121,122,123,124,125]. The gene discussed is TNFRSF10B; the disease is melanoma.