There are eight members of this family identified in humans: neuronal IAP/NAIP (BIRC1); cellular IAP1, also called cIAP1/HIAP2 (BIRC2); cellular IAP2, also called cIAP2/HIAP1 (BIRC3); X-linked IAP/XIAP/hILP (BIRC4); Survivin (BIRC5); BIR containing ubiquitin conjugating enzyme/BRUCE/Apollon (BIRC6); Melanoma IAP/ML-IAP/Livin (BIRC7); and IAP-like protein 2/hILP2/Ts-IAP (BIRC8). The gene discussed is BIRC5; the disease is melanoma.