A phase 1/2 trial of patients with newly diagnosed IDH-mutated AML who are ineligible for intensive induction therapy is utilizing 5-Aza in combination with ivosidenib 500 mg daily or enasidenib 100 mg or 200 mg daily for patients with IDH1 or IDH2 mutations, respectively [96]. Here, IDH1 is linked to acute myeloid leukemia.