A phase 1/2 trial of patients with newly diagnosed IDH-mutated AML who are ineligible for intensive induction therapy is utilizing 5-Aza in combination with ivosidenib 500 mg daily or enasidenib 100 mg or 200 mg daily for patients with IDH1 or IDH2 mutations, respectively [96]. The gene discussed is IDH2; the disease is acute myeloid leukemia.