SNCA and Parkinson disease: There is an increasing recognition of the involvement of TLRs in neuronal degeneration based on the following pieces of evidence: (i) relevant cells of the nervous system express TLRs; (ii) TLRs are activated by α-synuclein; (iii) their activation induces an inflammatory response that precedes neuronal loss; (iv) halting TLRs engagement delays PD progression [88].