IFNA1 and neoplasm: Moreover, in addition to direct tumor cytotoxicity due to its oncolytic properties, NDV-infected tumor cells were reported to induce the maturation of dendritic cell by type I interferon (IFN) [3,4], activation of antigen specific T cells [5], immunostimulatory effects such as the activation of NK cells by hemagglutinin-neuraminidase (HN) protein expressed on an infected cell surface [6], and increase in MHC class I expression [7].