In the tumor cells before rNDV infection, the expression of retinoic acid-inducible gene-I (RIG-I), toll-like receptor 3 (TLR3), interferon regulatory factor 3 (IRF-3), myxovirus resistance (Mx) 1, Mx 2, 2′-5′-oligoadenylate synthetase (OAS) 1a, OAS1b, OAS2, OAS3, and 2′-5′ oligoadenylate synthetase-like (OASL) 2 showed a significant negative correlation with the rNDV infection rate. The gene discussed is RIGI; the disease is neoplasm.