In 2015, by using similar multi-platform molecular approaches, the Asian Cancer Research Group (ACRG) developed a novel molecular classification for GC based on a pre-defined set of genetic pathways relevant to the biology of GC, including epithelial-mesenchymal transition (EMT), microsatellite instability, cytokine signaling and P53 activity [15]. This evidence concerns the gene TP53 and gastric cancer.