CD274 and cancer: Soon after, The Cancer Genome Atlas (TCGA) research group categorized GC into four main groups by introducing new technologies of large-scale genome sequencing analyses [14]: Epstein-Barr virus (EBV)-positive cancers (9% of all GC) characterized by DNA hypermethylation, a high frequency of PIK3CA mutations and PDL1/PDL2 overexpression, microsatellite instable (MSI, 22%) tumours, showing a very high number of mutations and DNA methylation sites and chromosome instable tumours (CIN, 50%) mainly coding for alteration in tyrosine kinase receptors and genome stable tumours (GS, 20%).