In the CIN subtype, some specific mutations are frequently found, i.e., in the TP53 gene and receptor tyrosine kinases (RTKs), as well as amplifications of cell cycle genes (cyclin E1, cyclin D1 and cyclin-dependent kinase 6) and of the gene that encodes the ligand vascular endothelial growth factor A (VEGFA) [14,64]. This evidence concerns the gene VEGFA and cervical squamous intraepithelial neoplasia.