In GC, the PI3K/AKT/mTOR pathway is frequently activated and associated with nodal metastasis: in 35–80% of GC cases, PI3KCA is overexpressed [27,28,29], and in 40–82% of GC cases, phosphorylation of AKT is described [36,37,38,39,40]. The gene discussed is AKT1; the disease is gastric cancer.