PIK3CA and neoplasm: They categorized GC into three main types: [13] a proliferative profile associated with a high genomic instability and TP53 gene mutation, a metabolic profile associated with a higher anaerobic glycolysis and resulting in tumour cells more sensitive to 5-FU therapy and a mesenchymal stem cell profile with a high capacity for self-renewal, immunomodulation and tissue regeneration showing a sensitivity to PIK3CA-mTOR pathway inhibitors.